Neurons communicate through electrical signals called action potentials. These rapid changes in membrane voltage allow information to zip along nerve cells. Understanding how neurons generate and transmit these signals is key to grasping how our nervous system functions.
Action potentials rely on the movement of ions across cell membranes. By exploring ion channels, resting potentials, and the steps of an action potential, we can see how neurons create and propagate these crucial electrical messages throughout the body.
Membrane Potential and Action Potentials
Ion channels and resting potential
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Top images from around the web for Ion channels and resting potential
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is the difference in electrical charge across a neuron's membrane when not conducting an impulse, typically around -70 mV with the inside more negative than the outside
Ion concentrations inside and outside the cell contribute to the resting potential, with high K+ concentration inside and high Na+ concentration outside
Ion channels allow specific ions to move across the membrane
K+ leak channels enable K+ to diffuse out of the cell along its concentration gradient
Na+ leak channels permit some Na+ to enter the cell
Na+/K+ pump actively transports ions to maintain concentration gradients, pumping 3 Na+ out and 2 K+ into the cell for each ATP consumed, helping maintain the resting potential
Sequence of action potential generation
occurs when a stimulus causes the to become less negative, triggering an action potential if it reaches the (around -55 mV)
Rising phase: Voltage- Na+ channels open, allowing rapid Na+ influx, causing the membrane potential to peak around +30 mV
Falling phase: Voltage-gated Na+ channels inactivate and close, while voltage-gated K+ channels open, allowing K+ efflux and membrane potential to return towards resting level
Afterhyperpolarization: Voltage-gated K+ channels remain open, briefly causing the membrane potential to become more negative than the resting potential
Refractory periods:
: Na+ channels are inactivated, preventing another action potential
: Na+ channels have partially recovered, requiring a stronger stimulus to trigger an action potential
Continuous vs saltatory conduction
in unmyelinated axons:
Action potential propagates continuously along the membrane, with of one segment causing depolarization of the adjacent segment
Slower conduction velocity compared to
in myelinated axons:
insulates the axon, preventing ion flow across the membrane
Action potentials occur only at (gaps in )
Depolarization at one node triggers depolarization at the next, causing the action potential to "jump" from node to node ()
Faster conduction velocity due to reduced membrane capacitance and increased membrane
Advantages of saltatory conduction:
Faster velocity allows rapid transmission over long distances (spinal cord)
Reduces energy requirements for action potential propagation
Synaptic Transmission and Neurotransmitter Release
Action potentials arriving at the axon terminal trigger