8.3 Pharmacogenomics and equitable access to tailored treatments
3 min read•july 18, 2024
combines genetics and drug science to create personalized treatments. It studies how genes affect drug responses, aiming to develop tailored therapies based on genetic profiles. This approach can optimize drug dosing and predict adverse reactions, leading to more effective treatments.
Ethical concerns arise around privacy, , and to genetic-guided treatments. There's a risk of and potential discrimination. Ensuring all individuals can benefit from pharmacogenomics, regardless of socioeconomic status, is crucial to avoid exacerbating .
Pharmacogenomics and Personalized Medicine
Concept of pharmacogenomics
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Gene-drug interaction | Pharmacovigilance Journal | Pharmacoepidemiology Researches View original
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Top images from around the web for Concept of pharmacogenomics
Frontiers | Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug ... View original
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Frontiers | Pathway-Based Drug Response Prediction Using Similarity Identification in Gene ... View original
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Gene-drug interaction | Pharmacovigilance Journal | Pharmacoepidemiology Researches View original
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Frontiers | Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug ... View original
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Frontiers | Pathway-Based Drug Response Prediction Using Similarity Identification in Gene ... View original
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Pharmacogenomics studies how genes influence an individual's response to drugs by combining pharmacology (the study of drugs) and genomics (the study of genes and their functions)
Aims to develop based on a person's genetic profile since genetic variations can affect drug absorption, metabolism, and effectiveness (cytochrome P450 enzymes)
Understanding these variations can help predict drug response and adverse reactions, enabling the development of targeted therapies that are more effective and have fewer side effects (warfarin dosing)
Allows for the optimization of drug dosing based on an individual's genetic makeup and helps identify patients who are likely to benefit from a specific treatment or experience adverse reactions (codeine metabolism)
Ethics of genetic-guided treatments
Privacy and confidentiality concerns arise because genetic information is highly personal and sensitive, with a risk of discrimination based on genetic data (employers, insurance companies)
Informed consent and autonomy require that patients be fully informed about the use of their genetic information in treatment decisions and respect for individual autonomy in deciding whether to undergo genetic testing and receive personalized treatments
Potential for genetic determinism exists if there is an overemphasis on genetic factors, leading to a deterministic view of health and disease, but it is important to consider non-genetic factors (environment, lifestyle) in treatment decisions
Equitable access to genetic testing and personalized treatments must be ensured so that all individuals, regardless of socioeconomic status, have access to the benefits of pharmacogenomics
Health Disparities and Equitable Access
Pharmacogenomics and health disparities
Pharmacogenomics may exacerbate existing health disparities because:
High cost of genetic testing and personalized treatments may limit access for disadvantaged populations
Lack of diversity in genetic research may lead to biased findings and inadequate representation of certain ethnic groups (African Americans, Hispanics)
Unequal access to healthcare resources, such as disparities in healthcare infrastructure and access to specialized care, may hinder the implementation of pharmacogenomics
Socioeconomic factors (income, education) can influence an individual's ability to benefit from personalized medicine
There is a need for equitable access to pharmacogenomic-based treatments by ensuring that the benefits of pharmacogenomics are distributed fairly across all segments of society and addressing systemic barriers to healthcare access and promoting inclusive research practices
Equitable access to pharmacogenomic treatments
Increasing diversity in genetic research is crucial by:
Ensuring adequate representation of different ethnic groups in genetic studies
Developing population-specific genetic databases to improve the accuracy and applicability of pharmacogenomic findings
Promoting public-private partnerships through collaboration between government, industry, and academic institutions to fund and advance pharmacogenomic research and developing innovative financing models to support the development and distribution of personalized treatments
Implementing policies to ensure equitable access by establishing guidelines for the fair allocation of pharmacogenomic-based treatments and providing financial assistance or subsidies to help low-income individuals access personalized medicine
Educating healthcare professionals and the public by training healthcare providers on the appropriate use and interpretation of pharmacogenomic data and raising public awareness about the benefits and limitations of personalized medicine to promote informed decision-making