ArrayExpress

Definition

ArrayExpress is a public database that stores and provides access to a wide range of functional genomics data, including gene expression and proteomics information. It is a key resource for researchers who want to analyze large-scale molecular data, supporting the integration of proteomics and genomics approaches in understanding biological systems and diseases.

5 Must Know Facts For Your Next Test

1. ArrayExpress was developed by the European Bioinformatics Institute (EBI) to facilitate the archiving and sharing of gene expression and other functional genomics datasets.
2. The database contains both raw and processed data, allowing researchers to perform their own analyses or use existing analyses provided by other scientists.
3. ArrayExpress is linked to various bioinformatics tools and resources, enabling users to visualize and interpret the data in meaningful ways.
4. It plays a significant role in promoting reproducibility in scientific research by providing a platform for sharing experimental results and methodologies.
5. Researchers can submit their own datasets to ArrayExpress, contributing to the global scientific community and enhancing the breadth of available data.

Review Questions

• How does ArrayExpress enhance the accessibility and usability of functional genomics data for researchers?
  • ArrayExpress enhances accessibility by providing a centralized platform where researchers can easily find, download, and analyze vast amounts of functional genomics data. This includes both raw and processed datasets, which allows users to conduct their own analyses or leverage existing interpretations. The user-friendly interface and integration with bioinformatics tools also make it easier for scientists to visualize results, fostering collaboration and innovation in the field.
• Discuss the importance of data submission to ArrayExpress and how it contributes to scientific collaboration.
  • Data submission to ArrayExpress is crucial as it allows researchers to share their findings with the wider scientific community. By depositing their datasets in a public repository, scientists enable others to replicate studies, validate findings, and build upon previous research. This collaborative approach not only promotes transparency but also accelerates discovery by pooling knowledge across different research groups and disciplines.
• Evaluate how ArrayExpress integrates with other databases and tools in the realm of proteomics and genomics, and its impact on advancing biological research.
  • ArrayExpress integrates with other databases like the Gene Expression Omnibus, as well as various bioinformatics tools that aid in data analysis and visualization. This interconnectedness enhances the ability of researchers to leverage complementary datasets from multiple sources, facilitating comprehensive analyses that combine genomics with proteomics. As a result, this synergy fosters a deeper understanding of complex biological processes and disease mechanisms, ultimately advancing research efforts in fields like personalized medicine and drug development.

Related terms

Gene Expression Omnibus: A public database that stores high-throughput gene expression data and allows users to query and analyze these datasets.

Proteomics: The large-scale study of proteins, particularly their functions and structures, which is essential for understanding cellular processes.

Microarray: A technology used to detect the expression of thousands of genes simultaneously, often utilized in conjunction with ArrayExpress for data storage.