Angiotensin converting enzyme (ACE)

Definition

Angiotensin converting enzyme (ACE) is an enzyme that converts angiotensin I to angiotensin II, a potent vasoconstrictor. It plays a crucial role in regulating blood pressure and fluid balance.

5 Must Know Facts For Your Next Test

1. ACE is primarily found in the lungs' capillaries.
2. Angiotensin II, produced by ACE, stimulates aldosterone secretion from the adrenal glands.
3. ACE inhibitors are used to treat hypertension and heart failure.
4. The renin-angiotensin-aldosterone system (RAAS) involves ACE as a key component.
5. ACE also degrades bradykinin, a peptide that causes blood vessels to dilate.

Review Questions

• What role does ACE play in the conversion of angiotensin I?
• How does ACE contribute to blood pressure regulation?
• Why are ACE inhibitors prescribed for hypertension?

Related terms

Renin: An enzyme secreted by the kidneys that initiates the RAAS by converting angiotensinogen to angiotensin I

Aldosterone: A hormone produced by the adrenal glands that increases sodium reabsorption and potassium excretion in the kidneys

Bradykinin: A peptide that promotes vasodilation and is broken down by ACE