Burkitt lymphoma

Definition

Burkitt lymphoma is a fast-growing type of non-Hodgkin lymphoma that originates from B lymphocytes. It is strongly associated with the Epstein-Barr virus (EBV).

5 Must Know Facts For Your Next Test

1. Burkitt lymphoma is most common in children and young adults, particularly in regions of Africa.
2. There are three main types: endemic, sporadic, and immunodeficiency-related Burkitt lymphoma.
3. The disease often presents with tumors in the jaw or abdomen.
4. Cytogenetic analysis commonly reveals translocations involving the MYC gene on chromosome 8.
5. Treatment typically involves intensive chemotherapy and has a high cure rate if diagnosed early.

Review Questions

• What virus is strongly associated with Burkitt lymphoma?
• Describe the typical presentation of Burkitt lymphoma in patients.
• What genetic abnormality is commonly found in Burkitt lymphoma cases?

Related terms

Epstein-Barr Virus (EBV): A herpesvirus that can cause infectious mononucleosis and is linked to several types of cancer.

Non-Hodgkin Lymphoma: A diverse group of blood cancers that includes any kind of lymphoma except Hodgkin's lymphomas.

MYC Gene: A gene that codes for a transcription factor involved in cell cycle progression, apoptosis, and cellular transformation; frequently altered in cancers.