5-alpha-reductase inhibitors are medications that block the action of the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT). They are commonly used to treat conditions like benign prostatic hyperplasia (BPH) and male pattern baldness.
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5-alpha-reductase inhibitors include drugs such as finasteride and dutasteride.
These inhibitors reduce DHT levels, leading to decreased prostate size and improved urinary flow in BPH patients.
Common side effects can include sexual dysfunction, such as decreased libido and erectile dysfunction.
They may take several months to show noticeable effects on symptoms.
These medications are contraindicated in women who are or may become pregnant due to potential birth defects.
Review Questions
Name two common drugs that belong to the class of 5-alpha-reductase inhibitors.
What is the primary mechanism of action for 5-alpha-reductase inhibitors?
List two potential side effects associated with the use of 5-alpha-reductase inhibitors.
Related terms
Benign Prostatic Hyperplasia (BPH): A condition characterized by an enlarged prostate gland causing urinary problems.
Dihydrotestosterone (DHT): An androgen hormone formed from testosterone that plays a role in the development of male characteristics and conditions like BPH.
Alpha Blockers: Medications that relax muscle tissue in blood vessels and the prostate, improving urine flow in BPH patients.