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An agonist is a substance that binds to a receptor and activates it to produce a biological response. Agonists can be drugs or endogenous compounds like hormones.
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Antagonist: A substance that binds to receptors but does not activate them, blocking the action of agonists.
Receptor: A protein molecule that receives chemical signals from outside a cell.
Efficacy: The ability of a bound drug to initiate a response at the molecular, cellular, tissue or system level.