👩🏻‍⚕️Pathophysiological Concepts in Nursing Unit 10 – Renal and Urinary System Pathophysiology

Anatomy Refresher

• The renal system consists of two kidneys, two ureters, the bladder, and the urethra
• Each kidney contains millions of nephrons, the functional units of the kidney
  • Nephrons are composed of a renal corpuscle (glomerulus and Bowman's capsule) and a renal tubule (proximal convoluted tubule, loop of Henle, distal convoluted tubule, and collecting duct)
• Blood enters the kidney through the renal artery, which branches into smaller arteries and arterioles
• Filtered blood exits the kidney via the renal vein
• Urine produced by the kidneys travels through the ureters to the bladder for storage before being eliminated through the urethra

Key Functions of the Renal System

• Regulates fluid and electrolyte balance by controlling the excretion and reabsorption of water, sodium, potassium, and other ions
• Maintains acid-base balance by excreting excess hydrogen ions and reabsorbing bicarbonate
• Filters waste products from the blood, such as urea, creatinine, and uric acid, and excretes them in the urine
• Produces and secretes hormones, including erythropoietin (stimulates red blood cell production), renin (regulates blood pressure), and calcitriol (active form of vitamin D)
• Regulates blood pressure through the renin-angiotensin-aldosterone system (RAAS)
  • Renin is released in response to decreased blood flow to the kidneys, leading to the production of angiotensin II and aldosterone
  • Angiotensin II causes vasoconstriction and increases blood pressure, while aldosterone promotes sodium and water retention

Common Renal Disorders

• Acute kidney injury (AKI): sudden decline in kidney function due to factors such as decreased blood flow, nephrotoxic agents, or urinary tract obstruction
• Chronic kidney disease (CKD): progressive loss of kidney function over time, often due to diabetes, hypertension, or glomerulonephritis
  • CKD is staged based on the estimated glomerular filtration rate (eGFR) and the presence of albuminuria
• Nephrotic syndrome: characterized by heavy proteinuria, hypoalbuminemia, edema, and hyperlipidemia
• Nephrolithiasis (kidney stones): formation of solid deposits in the kidneys or urinary tract, often composed of calcium oxalate or calcium phosphate
• Urinary tract infections (UTIs): bacterial infections affecting the bladder (cystitis), urethra (urethritis), or kidneys (pyelonephritis)
• Renal cell carcinoma (RCC): a type of kidney cancer originating in the lining of the proximal renal tubules

Diagnostic Tests and Procedures

• Urinalysis: examination of urine for abnormalities such as blood, protein, glucose, or bacteria
• Blood tests: assess kidney function by measuring serum creatinine, blood urea nitrogen (BUN), and electrolyte levels
• Estimated glomerular filtration rate (eGFR): calculated using serum creatinine, age, sex, and race to estimate kidney function
• Renal ultrasound: non-invasive imaging technique to visualize kidney structure and detect abnormalities such as cysts, stones, or tumors
• Computed tomography (CT) and magnetic resonance imaging (MRI): provide detailed images of the kidneys and urinary tract
• Renal biopsy: removal of a small sample of kidney tissue for microscopic examination to diagnose specific renal disorders

Treatment Approaches

• Medications: diuretics (furosemide) to manage fluid balance, antihypertensives (ACE inhibitors, ARBs) to control blood pressure and slow CKD progression, antibiotics for UTIs, and immunosuppressants for glomerulonephritis
• Dialysis: removes waste products and excess fluid from the blood when the kidneys are unable to do so effectively
  • Hemodialysis: blood is filtered through a machine and returned to the body
  • Peritoneal dialysis: a special solution is introduced into the abdominal cavity to absorb waste products and excess fluid
• Kidney transplantation: surgical replacement of a diseased kidney with a healthy kidney from a living or deceased donor
• Dietary modifications: low-sodium diet to manage hypertension and fluid retention, low-protein diet to reduce waste product accumulation in CKD, and fluid restriction in advanced CKD
• Lifestyle changes: smoking cessation, regular exercise, and maintaining a healthy weight to reduce the risk of CKD and its complications

Nursing Considerations

• Assess and monitor vital signs, fluid balance (intake and output), and weight changes
• Administer medications as prescribed and educate patients on their proper use and potential side effects
• Encourage adherence to dietary and fluid restrictions, and provide patient education on the importance of these modifications
• Monitor laboratory values (serum creatinine, BUN, electrolytes) and report abnormalities to the healthcare team
• Assess for signs and symptoms of complications, such as fluid overload, electrolyte imbalances, and infections
• Provide emotional support and education to patients and their families, especially those undergoing dialysis or awaiting kidney transplantation
• Collaborate with the interdisciplinary team (nephrologists, dietitians, social workers) to ensure comprehensive patient care

Case Studies and Clinical Applications

• A 45-year-old male with a history of type 2 diabetes presents with fatigue, nausea, and edema. Lab results show an eGFR of 30 mL/min/1.73m², indicating stage 4 CKD. The nursing plan of care should focus on medication management, dietary modifications, and patient education to slow disease progression and prevent complications.
• A 28-year-old female presents with dysuria, frequency, and suprapubic pain. Urinalysis reveals leukocytes, nitrites, and bacteria, confirming a diagnosis of acute cystitis. The nurse should administer antibiotics as prescribed, encourage increased fluid intake, and provide patient education on hygiene measures to prevent recurrent UTIs.
• A 60-year-old male with a history of hypertension and nephrolithiasis presents with severe flank pain and hematuria. CT imaging confirms the presence of a 5mm obstructing ureteral stone. The nursing plan of care should include pain management, monitoring for signs of infection, and preparing the patient for possible urological interventions (lithotripsy or ureteral stenting).

Key Takeaways and Review

• The renal system plays a crucial role in maintaining fluid, electrolyte, and acid-base balance, filtering waste products, and regulating blood pressure
• Common renal disorders include acute kidney injury, chronic kidney disease, nephrotic syndrome, nephrolithiasis, urinary tract infections, and renal cell carcinoma
• Diagnostic tests for renal disorders include urinalysis, blood tests, imaging studies (ultrasound, CT, MRI), and renal biopsy
• Treatment approaches vary depending on the specific disorder and may include medications, dialysis, kidney transplantation, dietary modifications, and lifestyle changes
• Nurses play a vital role in assessing, monitoring, and educating patients with renal disorders, as well as collaborating with the interdisciplinary team to ensure optimal patient outcomes
• Understanding the pathophysiology of renal disorders is essential for providing evidence-based, patient-centered care and promoting the best possible outcomes for patients with renal and urinary system conditions