💊Pharmacology for Nurses Unit 29 – Digestive System Basics for Nurses

Overview and Anatomy

• The digestive system consists of the gastrointestinal tract (GI tract) and accessory organs that work together to break down food, absorb nutrients, and eliminate waste
• The GI tract is a continuous tube that extends from the mouth to the anus, including the esophagus, stomach, small intestine, and large intestine
• Accessory organs include the liver, gallbladder, and pancreas, which produce enzymes and secretions to aid in digestion
• The digestive system is lined with mucosa, a layer of epithelial cells that secrete mucus to protect the lining and aid in the passage of food
• The walls of the GI tract contain smooth muscle layers that contract and relax to move food through the system (peristalsis)
• The small intestine is the longest part of the GI tract (approximately 20 feet long) and is divided into three sections: duodenum, jejunum, and ileum
• The large intestine (colon) is responsible for absorbing water and electrolytes from the remaining digestive matter and forming solid waste (feces)

Digestive Process Basics

• Digestion involves the mechanical and chemical breakdown of food into smaller components that can be absorbed and utilized by the body
• Mechanical digestion begins in the mouth with chewing (mastication) and continues in the stomach with churning and mixing
• Chemical digestion involves enzymes secreted by the salivary glands, stomach, pancreas, and small intestine to break down carbohydrates, proteins, and fats
• The process of swallowing (deglutition) involves the coordination of the tongue, pharynx, and esophagus to move food from the mouth to the stomach
• Absorption occurs primarily in the small intestine, where nutrients are transported across the intestinal wall and into the bloodstream or lymphatic system
• The liver plays a crucial role in digestion by producing bile, which emulsifies fats and aids in their absorption
• The pancreas secretes digestive enzymes (lipase, amylase, and trypsin) into the small intestine to further break down nutrients
• Undigested matter, along with bacteria and other waste products, is eliminated from the body through the process of defecation

Key Organs and Their Functions

• The mouth initiates digestion through chewing and the secretion of saliva, which contains the enzyme salivary amylase to begin breaking down carbohydrates
• The esophagus is a muscular tube that connects the pharynx to the stomach and uses peristaltic contractions to move food towards the stomach
• The stomach is a hollow, muscular organ that stores food, mixes it with digestive secretions (hydrochloric acid and pepsin), and releases it slowly into the small intestine
  • Hydrochloric acid (HCl) helps to kill bacteria and denature proteins, while pepsin begins the digestion of proteins
• The small intestine is the primary site of digestion and absorption, with the duodenum receiving secretions from the liver, gallbladder, and pancreas
  • The jejunum and ileum are responsible for the majority of nutrient absorption through their highly folded and vascularized walls (villi and microvilli)
• The large intestine absorbs water and electrolytes, forms feces, and houses a diverse population of bacteria (gut microbiome) that aid in digestion and immune function
• The liver is the largest gland in the body and performs numerous functions, including the production of bile, detoxification of harmful substances, and regulation of blood glucose levels
• The gallbladder stores and concentrates bile produced by the liver, releasing it into the duodenum when needed for fat digestion
• The pancreas is a glandular organ that secretes digestive enzymes into the small intestine and produces hormones (insulin and glucagon) to regulate blood sugar levels

Common Digestive Disorders

• Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the esophagus, causing symptoms such as heartburn and acid reflux
• Peptic ulcers are open sores that develop in the lining of the stomach or duodenum, often caused by the bacterium Helicobacter pylori or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs)
• Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis, which are characterized by chronic inflammation of the GI tract
  • Crohn's disease can affect any part of the GI tract, while ulcerative colitis is limited to the colon and rectum
• Irritable bowel syndrome (IBS) is a functional disorder characterized by abdominal pain, bloating, and changes in bowel habits (diarrhea or constipation) without underlying structural abnormalities
• Celiac disease is an autoimmune disorder triggered by the ingestion of gluten, a protein found in wheat, barley, and rye, leading to damage of the small intestine's lining
• Diverticulitis occurs when small pouches (diverticula) that develop in the colon become inflamed or infected, causing abdominal pain, fever, and changes in bowel habits
• Colorectal cancer is a malignant growth that develops in the colon or rectum, often beginning as a benign polyp and progressing over time
• Gallstones are hardened deposits of bile that can form in the gallbladder, potentially causing pain (biliary colic) and inflammation (cholecystitis)

Pharmacological Interventions

• Antacids (calcium carbonate, magnesium hydroxide) neutralize stomach acid and provide relief from heartburn and indigestion
• H2 receptor antagonists (ranitidine, famotidine) reduce stomach acid production and are used to treat GERD and peptic ulcers
• Proton pump inhibitors (PPIs) such as omeprazole and lansoprazole are more potent acid suppressants used for GERD, peptic ulcers, and Zollinger-Ellison syndrome
• Prokinetics (metoclopramide) stimulate GI motility and are used to treat gastroparesis and GERD
• Antibiotics (amoxicillin, clarithromycin) are used in combination with PPIs to eradicate Helicobacter pylori infections and treat peptic ulcers
• Laxatives (polyethylene glycol, senna) are used to treat constipation by increasing stool volume, softening stool, or stimulating bowel movements
• Antidiarrheals (loperamide) slow intestinal motility and are used to manage acute diarrhea and reduce fluid loss
• Anti-inflammatory agents (5-aminosalicylates, corticosteroids) are used to reduce inflammation in IBD and manage flare-ups
• Immunomodulators (azathioprine, methotrexate) and biologics (infliximab, adalimumab) are used to induce and maintain remission in IBD by targeting the immune system
• Bile acid sequestrants (cholestyramine) bind to bile acids in the intestine and are used to treat bile acid malabsorption and diarrhea

Nursing Considerations

• Assess patients for signs and symptoms of digestive disorders, such as abdominal pain, changes in bowel habits, nausea, vomiting, and weight loss
• Monitor patients' nutritional status and provide guidance on dietary modifications based on their specific digestive disorder (low-fat diet for gallstones, gluten-free diet for celiac disease)
• Administer medications as prescribed and educate patients on their proper use, potential side effects, and importance of adherence
• Encourage patients to maintain a healthy lifestyle, including regular exercise, stress management, and avoidance of triggers (spicy foods, alcohol, smoking)
• Assist patients in managing pain and discomfort associated with digestive disorders through non-pharmacological interventions (relaxation techniques, heat therapy)
• Monitor patients for signs of complications, such as dehydration, malnutrition, or gastrointestinal bleeding, and intervene as necessary
• Collaborate with interdisciplinary team members (gastroenterologists, dietitians, surgeons) to provide comprehensive care and ensure optimal patient outcomes
• Provide emotional support and encourage patients to express their concerns and feelings related to their digestive disorder and its impact on their quality of life

Patient Education and Care

• Teach patients about the anatomy and physiology of the digestive system to help them better understand their condition and the importance of adhering to treatment plans
• Provide written materials and resources to reinforce verbal education and allow patients to review information at their own pace
• Instruct patients on the proper use of medications, including timing, dosage, and potential side effects, and emphasize the importance of not discontinuing medications without consulting their healthcare provider
• Encourage patients to keep a food and symptom diary to identify potential triggers and guide dietary modifications
• Teach patients about the importance of staying hydrated and replacing electrolytes, especially during episodes of diarrhea or vomiting
• Educate patients on the signs and symptoms of complications and when to seek medical attention (severe abdominal pain, bloody stools, persistent vomiting)
• Provide guidance on stress management techniques (deep breathing, meditation, yoga) and their potential benefits for digestive health
• Emphasize the importance of regular follow-up appointments and screenings (colonoscopy for colorectal cancer) to monitor the progress of their condition and adjust treatment plans as needed
• Encourage patients to join support groups or seek counseling to help cope with the emotional and social aspects of living with a chronic digestive disorder

Related Diagnostic Tests

• Endoscopy involves the use of a flexible tube with a camera (endoscope) to visualize the inside of the digestive tract, allowing for the diagnosis of conditions such as GERD, peptic ulcers, and IBD
  • Upper endoscopy (esophagogastroduodenoscopy or EGD) examines the esophagus, stomach, and duodenum
  • Colonoscopy examines the entire colon and rectum
• Biopsy involves the removal of a small tissue sample during endoscopy for microscopic examination to diagnose conditions such as celiac disease, IBD, and colorectal cancer
• Imaging studies such as X-rays, computed tomography (CT) scans, and magnetic resonance imaging (MRI) can help visualize the digestive organs and detect abnormalities (tumors, inflammation, obstruction)
• Barium studies (upper GI series, barium enema) use contrast material to visualize the digestive tract on X-rays and detect ulcers, strictures, or other abnormalities
• Stool tests can detect the presence of blood (fecal occult blood test), inflammation (fecal calprotectin), or infections (stool culture, ova and parasite exam)
• Breath tests can diagnose conditions such as Helicobacter pylori infection (urea breath test) and small intestinal bacterial overgrowth (SIBO) by measuring the presence of specific gases
• Esophageal manometry measures the strength and coordination of esophageal contractions and can help diagnose motility disorders such as achalasia
• Gastric emptying study (scintigraphy) assesses the rate at which food leaves the stomach and can diagnose gastroparesis
• Liver function tests (LFTs) measure the levels of enzymes and proteins in the blood to assess liver function and detect inflammation, damage, or obstruction of the bile ducts