10.1 Proteomics in disease diagnosis and prognosis
2 min read•july 25, 2024
Proteomics is revolutionizing disease diagnosis and prognosis. By analyzing proteins in our bodies, scientists can spot diseases early, predict outcomes, and tailor treatments. This powerful approach is changing how we detect and manage illnesses.
From to heart disease, proteomics is uncovering new that give doctors crucial insights. While challenges remain, the potential for and improved patient care is huge. It's an exciting time in medical research.
Proteomics in Disease Diagnosis and Prognosis
Proteomics for disease biomarkers
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Frontiers | Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer ... View original
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Frontiers | Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD View original
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Frontiers | An Integrated Quantitative Proteomics Workflow for Cancer Biomarker Discovery and ... View original
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Frontiers | Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer ... View original
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Frontiers | Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD View original
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Top images from around the web for Proteomics for disease biomarkers
Frontiers | Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer ... View original
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Frontiers | Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD View original
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Frontiers | An Integrated Quantitative Proteomics Workflow for Cancer Biomarker Discovery and ... View original
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Frontiers | Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer ... View original
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Frontiers | Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD View original
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Protein biomarkers measurable proteins indicate biological states or conditions
detect disease presence
Prognostic biomarkers predict disease outcome
Predictive biomarkers forecast treatment response
Proteomic approaches for biomarker discovery
-based techniques analyze protein mass and abundance
Antibody-based methods detect specific proteins ()
simultaneously measure multiple proteins
analyzes protein expression differences between healthy and diseased states
Identifies up-regulated or down-regulated proteins
Reveals potential
(PTMs) play crucial role in disease progression
PTM-specific biomarkers indicate disease states ( in cancer)
changes in diabetes
Protein biomarker discovery process
Biomarker discovery phase
Sample collection and preparation from diverse patient cohorts
using mass spectrometry
Data analysis and candidate biomarker selection based on
Verification phase
focus on specific proteins
Larger sample cohorts validate initial findings
Statistical validation ensures reproducibility
Clinical validation phase
assess biomarker performance
assessment determine diagnostic accuracy
Reproducibility testing across multiple laboratories
for biomarker validation ensure clinical relevance