The central nervous system relies on a complex network of blood vessels to function. Internal carotid and supply the brain, while spinal arteries nourish the spinal cord. The provides crucial collateral circulation, ensuring a backup blood supply.
, produced in the , circulates through the brain's and spinal cord's central canal. It cushions the brain, removes waste, and maintains homeostasis. Disruptions in blood flow or CSF dynamics can lead to serious conditions like stroke.
Circulatory Supply to the Central Nervous System
Blood vessels of central nervous system
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Arterial supply to the brain consists of and
give rise to , , and supplying the cerebral hemispheres
Vertebral arteries join to form the , which branches into and supplying the brainstem and cerebellum
is an anastomosis of cerebral arteries (anterior cerebral, middle cerebral, posterior cerebral, and communicating arteries) providing collateral circulation to the brain
Venous drainage of the brain occurs through and
Dural venous sinuses (superior sagittal, inferior sagittal, straight, transverse, and ) collect blood from the brain and drain into the internal
Internal jugular veins carry blood from the brain and head back to the heart
Arterial supply to the spinal cord is provided by the and
supplies the anterior two-thirds of the spinal cord
Posterior spinal arteries supply the posterior one-third of the spinal cord
Venous drainage of the spinal cord occurs through the and , which drain into the
Regulation of cerebral blood flow
maintains constant despite changes in systemic blood pressure
ensures that active brain regions receive increased blood flow to meet metabolic demands
The regulates the passage of substances between the bloodstream and the central nervous system, protecting the brain from harmful substances
Ventricular System and Cerebrospinal Fluid
Components of brain ventricular system
are the largest ventricles located in the cerebral hemispheres
(foramen of Monro) connects each lateral ventricle to the allowing flow
is a narrow, midline cavity located in the diencephalon (thalamus and hypothalamus)
(aqueduct of Sylvius) connects the third ventricle to the enabling CSF circulation
is a diamond-shaped cavity located in the hindbrain (pons and medulla oblongata)
Three openings: two (foramina of Luschka) and a (foramen of Magendie) allow CSF to exit the ventricular system and enter the
Central canal is a narrow, cylindrical space that extends through the center of the spinal cord, continuous with the fourth ventricle
Cerebrospinal fluid dynamics
Production of CSF occurs primarily in the choroid plexuses, highly vascularized structures located in the ventricles
Choroid plexuses secrete CSF by actively transporting ions and water from the blood into the ventricular space
lining the ventricles also contribute to CSF production, although to a lesser extent than the choroid plexuses
Circulation of CSF follows a unidirectional flow pattern:
CSF is produced in the
Flows through the into the third ventricle
Passes through the into the fourth ventricle
Exits the ventricular system through the lateral and median apertures into the surrounding the brain and spinal cord
Reabsorbed into the venous system via and granulations, which are projections of the that protrude into the dural venous sinuses
Functions of CSF include:
Mechanical protection by cushioning and supporting the brain within the skull, reducing the effective weight of the brain and preventing injury
Chemical protection by removing metabolic waste products and toxins from the central nervous system
Maintaining homeostasis by regulating and providing buoyancy to the brain, allowing it to float in the CSF
The facilitates the clearance of metabolic waste products from the brain through CSF-interstitial fluid exchange
Circulatory Disruptions and Stroke
Circulatory disruptions vs stroke occurrence
occurs when blood vessels supplying the brain become blocked, leading to oxygen and nutrient deprivation in the affected brain tissue
happens when a blood clot (thrombus) forms within a cerebral artery, often due to atherosclerotic plaque rupture or endothelial damage
occurs when a blood clot (embolus) forms elsewhere in the body (e.g., heart or carotid arteries) and travels through the bloodstream to lodge in a cerebral artery
occurs when blood vessels in the brain rupture, causing bleeding and increased intracranial pressure that compresses brain tissue
is bleeding within the brain tissue itself, often due to chronic or cerebral amyloid angiopathy
is bleeding in the subarachnoid space surrounding the brain, frequently caused by a ruptured cerebral aneurysm
Risk factors for stroke include:
, which can damage blood vessels and increase the risk of both ischemic and hemorrhagic strokes
, the buildup of fatty plaques in the arteries, narrowing the lumen and increasing the risk of thrombosis and embolism
, an irregular heart rhythm that can cause blood to pool and clot in the heart, increasing the risk of embolic stroke
, which can damage blood vessels and increase the risk of atherosclerosis and thrombosis
Smoking, which can damage blood vessels, increase blood pressure, and promote atherosclerosis
Age and family history, as the risk of stroke increases with age and a family history of stroke may indicate a genetic predisposition